Texas at Toronto 12:37 PM ET
The Toronto Blue Jays aim for their first series sweep at home in nearly four months when they cap a three-game set with the reeling Texas Rangers on Wednesday. After a 19-4 shellacking to begin the series, the Blue Jays picked up a tidy 3-0 triumph in Tuesday's matchup.
Baltimore at NY Yankees 1:05 PM ET
The Baltimore Orioles will have one final chance to end a miserable slide against the New York Yankees when the American League East foes finish a four-game series in Yankee Stadium on Wednesday afternoon. New York's 8-3 win Tuesday gave it 15 consecutive wins over the last-place Orioles - six in the past nine days - and a 16-2 advantage in the season series.
Boston at Cleveland 1:10 PM ET
Third baseman Rafael Devers looks to follow up a historic performance when his Boston Red Sox go after a series victory in the rubber match of a three-game set Wednesday afternoon against the host Cleveland Indians. Devers became the first Red Sox player since Nomar Garciaparra in 2003 to record six hits in a game (four doubles) as Boston coughed up a five-run lead before earning a 7-6 victory in 10 innings Tuesday to even the series.
Houston at Chi. White Sox 2:10 PM ET
George Springer looks to record his fourth consecutive multi-hit performance when the Houston Astros visit the Chicago White Sox on Wednesday afternoon for the finale of their three-game series. Springer notched two hits as Houston split a doubleheader on Tuesday and has gone 7-for-13 over his last three games.
Minnesota at Milwaukee 2:10 PM ET
The Minnesota Twins on Monday found themselves in second place for the first time since April 20 but regained the top spot in the American League Central one day later and look to stay there when they visit the Milwaukee Brewers on Wednesday afternoon for the finale of their two-game interleague series. Marwin Gonzalez belted a go-ahead, three-run homer in the eighth inning as the Twins posted a 7-5 win on Tuesday to move one-half game ahead of Cleveland in the division.
Arizona at Colorado 3:10 PM ET
Raimel Tapia is proving to be a rare bright spot for the struggling Colorado Rockies, who have lost 12 of their last 16 games and 21 of their last 28. Tapia is batting .455 during his eight-game hitting streak to lead the Rockies, who look to avoid a sweep in their three-game series against the visiting Arizona Diamondbacks on Wednesday afternoon.
Tampa Bay at San Diego 3:40 PM ET
The Tampa Bay Rays are taking on the look of a playoff team, armed with the best road record in baseball and a strong historical trend in their corner. Tampa Bay on Wednesday afternoon tries for its sixth straight victory after setting a club record with its ninth win in a row away from home when it goes for a three-game sweep of the San Diego Padres, who may be without top rookie Fernando Tatis Jr.
Oakland at San Francisco 3:45 PM ET
The San Francisco Giants escaped with a victory in the opener of the Bay Bridge Series to reach the .500 mark and remain in the hunt for a wild-card spot in the National League. They look to complete a two-game sweep and extend their winning streak to four games when they host the Oakland Athletics on Wednesday afternoon.
Cincinnati at Washington 4:05 PM ET
Stephen Strasburg hopes the third time is the charm on Wednesday as he attempts to match a career high in wins when the Washington Nationals vie for a three-game series sweep against the visiting Cincinnati Reds. Strasburg, who won 15 games in 2012, 2016, 2017, emerged victorious in seven straight starts before surrendering five homers in his last two trips to the mound.
Chi. Cubs at Philadelphia 7:05 PM ET
Cole Hamels will take the mound in the City of Brotherly Love for the first time since pitching for the Phillies in 2015 when the Chicago Cubs continue their three-game series against Philadelphia on Wednesday. Hamels, who did not pitch for the Cubs when they visited Philly last year, highlighted his first 10 seasons with the Phillies by being named the World Series MVP in 2008.
LA Dodgers at Miami 7:10 PM ET
Three-time Cy Young Award winner Clayton Kershaw was scheduled to start Tuesday's series opener at the Miami Marlins, but the Los Angeles Dodgers decided earlier in the day to hold back their ace left-hander an extra day. Kershaw was not missed in Tuesday's 15-1 rout and will pitch on six days' rest when the teams resume the three-game set on Wednesday night.
Seattle at Detroit 7:10 PM ET
The Seattle Mariners snapped out of a funk with a four-game sweep of Detroit last month and halted another slump with a return matchup against the Tigers on Tuesday. The Mariners have won eight in a row in the series with Detroit and are 5-0 this season entering the second of a three-game series against the Tigers on Wednesday night at Comerica Park.
NY Mets at Atlanta 7:20 PM ET
Ronald Acuna Jr. may not win the National League MVP award given strong seasons by Christian Yelich and Cody Bellinger, but the Atlanta Braves outfielder continues his impressive summer surge entering Wednesday’s home game against the New York Mets. The 21-year-old Acuna slugged his 34th homer and became the first NL player this season to reach 100 runs scored in Tuesday’s 5-3 victory, finishing with two hits while throwing out a runner at home plate.
Pittsburgh at LA Angels 8:07 PM ET
The Pittsburgh Pirates have followed a dreadful stretch with a pair of explosive victories. Pittsburgh looks to build on the sudden momentum when it closes a three-game road series against the struggling Los Angeles Angels on Wednesday.
St. Louis at Kansas City 8:15 PM ET
The St. Louis Cardinals have put their road troubles behind them as they go for a two-game sweep of the host Kansas City Royals on Wednesday. St. Louis improved to 38-19 all-time at Kauffman Stadium with Tuesday's 2-0 victory that snapped a five-game slide away from home and moved it within one game of the first-place Chicago Cubs in the National League Central while maintaining its No. 2 spot in the wild-card race.