NY Yankees at Boston 1:10 PM ET
The New York Yankees and Boston Red Sox - arguably the biggest rivals in U.S. sports history - have clashed more than 2,000 times but Saturday's meeting in London will be the most unique as Major League Baseball is played for the first time in Europe. The two-game series will be contested at London Stadium - capacity 66,000 - with dimensions of 330 feet down the lines and 385 feet to center field braced by a 16-foot wall, and foul territory more than 4,000 square feet greater than in Oakland.
Cleveland at Baltimore 4:05 PM ET
The Baltimore Orioles came into the weekend with losses in 13 of their last 14 games and the worst record in the majors but they looked like a different team in Friday's series opener. The Orioles will try to follow up a rare lopsided victory when they host the Cleveland Indians in the second of a three-game series on Saturday afternoon.
Kansas City at Toronto 4:07 PM ET
The Toronto Blue Jays took out some of the frustration they felt after a rough road trip on the Kansas City Royals on Friday, earning a 6-2 victory and snapping a three-game slide. The Blue Jays will try to keep the power coming when they host the Royals in the second of a four-game series on Saturday.
Texas at Tampa Bay 4:10 PM ET
The Tampa Bay Rays will hand the ball to left-hander Brendan McKay for his major-league debut Saturday afternoon when they host the red-hot Texas Rangers for the second of a three-game series. McKay, the fourth overall pick in the 2017 draft and the No. 2 prospect in all of baseball according to MLB Pipeline, has dominated in the minor leagues this year and gets a chance against one of the most lethal offenses in the American League.
Atlanta at NY Mets 4:10 PM ET
After becoming the second team in the National League to reach 25 wins away from home, the Atlanta Braves look to continue that success when they resume their three-game set at the New York Mets on Saturday afternoon. Atlanta improved to 5-3 on its 10-game road trip with a 6-2 victory in the series opener to boost its lead in the NL East to 5 1/2 games.
Chi. Cubs at Cincinnati 4:10 PM ET
The Chicago Cubs may have lost much more than a game in the series opener against the Cincinnati Reds, watching left-hander Cole Hamels exit Friday's game after only one inning due to a left oblique sprain. Forced to use their bullpen for seven innings, the Cubs will hope for a solid outing from Jose Quintana in the second of a three-game set Saturday afternoon.
Philadelphia at Miami 4:10 PM ET
The Philadelphia Phillies could not build on a four-game winning streak in the series opener and look to end their misery against the host Miami Marlins when the National League East rivals meet for the second of three contests Saturday afternoon. The Phillies won four in a row against the New York Mets at home to start the week but dropped a 6-2 decision at NL-worst Miami for their four straight loss against the Marlins.
Washington at Detroit 4:10 PM ET
The surging Washington Nationals look to stay perfect on their current road trip and match their longest winning streak of the season when they continue a three-game series at the Detroit Tigers on Saturday. A 3-1 victory in Friday's series opener gave the Nationals four wins in a row to start the trip and 22 victories in their last 31 games overall.
Minnesota at Chi. White Sox 4:12 PM ET
The Minnesota Twins will try to avoid their first three-game losing streak of the season when they continue a three-game series at the Chicago White Sox on Saturday. After dropping an 18-inning marathon to Tampa Bay on Thursday at home, the Twins lost the opener 6-4 in Chicago.
LA Dodgers at Colorado 8:15 PM ET
The Los Angeles Dodgers owe exactly half of their 12-game advantage in the National League West to their success against the Colorado Rockies, who finally solved the riddle of the six-time defending division champions on Friday. The Rockies set their sights on back-to-back victories against the Dodgers for the first time since August on Saturday, when the top two teams in the NL West continue their four-game series in Colorado.
Seattle at Houston 8:15 PM ET
Justin Verlander looks to become the first 11-game winner in the major leagues when the Houston Astros host the Seattle Mariners on Saturday for the middle contest of their three-game series. Verlander ranks third in the American League in ERA (2.67) and strikeouts (142) while appearing to be a lock for his eighth All-Star appearance.
Pittsburgh at Milwaukee 8:15 PM ET
The Pittsburgh Pirates began the month at the break-even mark and very well could end it there, but their path from one to the other has been anything but normal. The Pirates hope to move within one game of .500 on Saturday, when they attempt to defeat the host Milwaukee Brewers a second straight time after dropping six of their first seven meetings this season.
Arizona at San Francisco 10:05 PM ET
The San Francisco Giants’ search for a regular left fielder may have finally ended with the arrival of Alex Dickerson, who has reached base safely in each of his first eight games with the team. Dickerson looks to extend the streak Saturday when the Giants continue their four-game series against the visiting Arizona Diamondbacks.
Oakland at LA Angels 10:07 PM ET
The Oakland Athletics attempt to remain successful on their road trip when they visit the Los Angeles Angels on Saturday for the third contest of their four-game series. Oakland has won three of the first four games on its trek after posting a 7-2 victory on Friday.
St. Louis at San Diego 10:10 PM ET
The San Diego Padres are above .500 at the midway point of the season for the first time in nine years as they host the St. Louis Cardinals on Saturday for the middle contest of their three-game series. Fernando Tatis Jr. and Eric Hosmer hit solo homers in Friday's 3-1 triumph as the Padres improved to 41-40, their best 81-game record since enjoying a 48-33 first half in 2010.